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AI Detects Rare Syndromes From Images January 9, 2019

Posted by stuffilikenet in Applications, Photography, Science, Star Trek Technology.
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Rare disorders often present with patterned discoloration of the epidermis, distortion of features and other visibly-detectable aberrations in appearance. Marfan’s syndrome presents with long, flexible body type. Noonan syndrome may present wide-set eyes, and Down’s syndrome is well-known to nearly everyone. Now, researchers have developed a facial analysis framework, DeepGestalt, using computer vision and deep learning algorithms, that quantifies similarities to hundreds of genetic syndromes based on unconstrained 2D images. DeepGestalt is currently trained with over 26,000 patient cases from a rapidly growing phenotype-genotype database, consisting of tens of thousands of validated clinical cases, curated through a community-driven platform. DeepGestalt currently achieves 91% top-10-accuracy in identifying over 215 different genetic syndromes and has outperformed clinical experts in three separate experiments.

In results published in Nature Medicine, DeepGestalt  outperformed doctors in diagnosing patients with Angelman syndrome and Cornelia de Lange syndrome versus other disorders, and in separating patients with different genetic subtypes of Noonan syndrome.

It’s a neat study in that it controls for a bunch of conditions including ethnicity and gender, so it’s a bit more robust than previous studies.

 

Homework: [PDF] https://arxiv.org/abs/1801.07637

Modest Plasma Globe Hack December 12, 2018

Posted by stuffilikenet in Awesome, Science, Star Trek Technology, Toys, Video.
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Type II Diabetes Prediction by Skin Autofluorescence November 27, 2018

Posted by stuffilikenet in Awesome, Science, Star Trek Technology.
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Despite amazing improvements in understanding of diabetes, something like one in ten humans is Type II diabetic.  Take a minute to absorb that; about half a billion people. Very, very obviously better medical tools and interventions are needed, since we as a species seem incapable of eating right (there are other factors, too; I don’t blame anyone for enjoying food). Researchers in the Netherlands and Canada have published a study using skin autofluorescence to detect some markers which accurately predict onset of Type II diabetes in the short term of about four years…unless they die first.

It’s a good study; 72,000 patients. “After a median follow-up of 4 years (range 0.5–10 years), 1056 participants (1.4%) had developed type 2 diabetes, 1258 individuals (1.7%) were diagnosed with CVD, while 928 (1.3%) had died. Baseline skin autofluorescence was elevated in participants with incident type 2 diabetes and/or CVD [(myocardial infarction, coronary interventions, cerebrovascular accident, transient ischemic attack, intermittent claudication or vascular surgery)-ed.] and in those who had died (all p < 0.001), compared with individuals who survived and remained free of the two diseases. Skin autofluorescence predicted the development of type 2 diabetes, CVD and mortality, independent of several traditional risk factors, such as the metabolic syndrome, glucose and HbA1c.”.

In high-tech terms this isn’t tough; a one-inch square is illuminated with 300-420nm UV and the fluorescence at 420-600nm.  They took the ratio of the two.  They did chemical workups on fasting blood samples as well: “On the same day, HbA1c (EDTA-anticoagulated) was analyzed using an NGSP-certified turbidimetric inhibition immunoassay on a Cobas Integra 800 CTS analzser (Roche Diagnostics Nederland, Almere, the Netherlands). Serum creatinine was measured on a Roche Modular P chemistry analyzer (Roche, Basel, Switzerland) and renal function was calculated as estimated (e)GFR with the formula developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) [31]. Total cholesterol and HDL-cholesterol were measured using an enzymatic colorimetric method, triacylglycerol using a colorimetric UV method, and LDL-cholesterol using an enzymatic method, on a Roche Modular P chemistry analyzer (Roche). Fasting blood glucose was measured using a hexokinase method.”

Without doing the rather more expensive bloodwork, a skin fluorescence gizmo could be made cheaply available.  It’s an excellent first step.

Homework:

Manufactured Human Organs November 20, 2018

Posted by stuffilikenet in 3D Printing, Awesome, Brain, Science, Star Trek Technology.
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Scientists at Tel Aviv University have created human organs (little ones but, hey) from a bit of biopsied tissues.  They separated the cells from the rest, induced pluripotency and built up organs in differentiated cell layers on a gel scaffolding.  They were able to grow cardiac, spinal and cortical cells from the biopsy sample.

This is critical to success: the cells are the patient’s own cells, with little chance of immune system rejection.  These guys (Tal Dvir, Reuven Edri, NAdav Noor, Idan Gal, Dan Peer and Irit Gat Viks) are currently engaged in regenerating an injured spinal cord and an infarcted heart with spinal cord and cardiac implants. They have also begun to investigate the potential of human dopaminergic implants to treat Parkinson’s disease in animal models.

They have big plans for this technology: “We believe that the technology of engineering fully personalized tissue implants of any type will allow us to regenerate any organ with a minimal risk of immune response,” Prof. Dvir concludes.

Homework: Reuven Edri et al, Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants, Advanced Materials (2018). DOI: 10.1002/adma.201803895

Getting There, One Piece at a Time January 24, 2017

Posted by stuffilikenet in Awesome, Geek Stuff, Star Trek Technology, Toys.
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Open the Alexa app on your phone.

Use the More icon (the hamburger) in the upper left corner.

Select Settings.

Select the device whose wake word you wish to change.

Tap the Wake Word setting.

Select Computer from the drop-down.

You are done.

I would like to point out that Star Trek has so influenced culture that the United Federation of Planets is likely to happen any time now…we just need more planets.  We already have Majel Barret’s voice phonemes.  Now we need Google to sync up, a bit better response to voice meaning (the voice vector thing should help), a truthiness evaluator and bingo! Star Trek in your phone/home/office/laboratory/dungeon/whatever.

Amazon Moto G Play Phone January 19, 2017

Posted by stuffilikenet in Applications, Geek Stuff, Science, Star Trek Technology, Toys.
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People in the know (i. e., my readers) are aware that I take my phones seriously, and have for three smart phones now. Well, smart-enough phones, I guess.  I mean I had an HTC 8125 ancient creaking phone with one of Microsoft’s many, many failed phone operating systems (are they really up to FOUR commercially-failed systems, and about to go for FIVE?), which did some things I needed in a phone: calculator (never used it, but could have), texting (would have used it but did not…not sure that it could, now that I think on it), took [execrable] photographs (look back in this blog far enough and you will find them, along with scathing reviews of the image quality) but at least ran the flash card app I wrote for it, among others (my writing them would not have been necessary if MS has anything like an app store.  Just sayin’), and played my beloved audio books during my [endless] commute.1

Still, it was not the optimum device.  My next phone (Samsung Galaxy S3 i9250) was a considerable improvement, in that the camera focused closely enough to copy text.  It ran Android apps mostly without complaint (even ones I had written myself), texted my children and played Bluetooth music and audio books without complaint, even after having survived several cracked glass incidents (to be fair, I never did repair the glass.  It looked like a vandalized cathedral when it finally died). It was a vast improvement, and I cried bitter tears indeed2 when it suddenly stopped letting me make telephone calls.

Now I have the aforementioned Amazon Moto G Play phone, and I must say it is an improvement on my previous experiences (except for the annoying notifications.  How the #$%^&* do I turn them off?) in speed, in reception and in sound clarity (although not volume).  The camera is much better (see recent postings about the weather, blue jay invasion, etc.) and the Android version is 6.0, which is 1.7 better than previous.  And it was cheap: $99 for the phone with advertising, $149 without.  I have been unable to figure out how to replace the bootloader to get rid of the advertisements (which would violate my agreement and would be Bad And Wrong), but it works so well I don’t care at all.

EXCITING, HORRIBLE UPDATE: can’t root the phone to use adb wireless.  This is totally bogus.

1Not sure that’s the longest run-on sentence I have ever written, but Baron Bulwer-Lytton must feel somewhat threatened in his cozy grave.

2Mostly because I had spent a fortune on it.  Don’t fear; this story DOES have a happy ending.

Too Much Science to Read, Let Alone Review November 15, 2016

Posted by stuffilikenet in Awesome, Brain, Brilliant words, Geek Stuff, Science, Star Trek Technology, Toys, Uncategorizable.
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It’s been a banner week for science geeks, nerds, and squints. The locked-in lady gets to at least shout from her prison quietlyGoogle has radar sensitive enough to not only find objects but identify them by their radar signature and perovskite is once again breaking solar-conversion efficiency records.

Ordinarily I would give you a breakdown of each of these nifty developments, but more are coming and I may want to return to these later when I am not pressed for time.  Follow the links above; there are others as well that you will find more well constructed than my chicken scratchings, I’m sure.

Brain-Computer Interface Now in Use at Home!!! November 15, 2016

Posted by stuffilikenet in Applications, Awesome, Brain, Geek Stuff, Science, Star Trek Technology, Toys, Uncategorizable.
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A 58-year-old woman (“HB”) with ALS has had a functioning brain-computer interface (BCI) for a while now, and is able to communicate (slowly) with the outside world. She was facing total lock-in Real Soon Now, so any device which offers communication ability is welcome.

What it is:

A diagram illustrating the setup and use of the ECoG implant.

Electrode strips at the top laid across her brain like band-aids read faint electrical signals.  With training HB was able to “type” fairly quickly (words per minute, but still).  More work remains to be done on the interfacing software (I am imagining more inputs and a neural network to interpret her thoughts more and more efficiently), and HB is ecstatic to have a way t live in the world.  She would like to use the interface to control a wheelchair, for example, but that is a ways off.

 

Homework:  Vansteensel, Mariska J. et. al., Fully Implanted Brain–Computer Interface in a Locked-In Patient with ALS, New England Journal of Medicine November 12, 2016 DOI: 10.1056/NEJMoa1608085

Update: New Scientist has an excellent writeup as well.

Brain-Computer Interface Restores Locomotion November 9, 2016

Posted by stuffilikenet in Awesome, Brain, Science, Star Trek Technology, Toys.
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You heard me. Watch the video and be amazed.

The researchers think it could be ready for human trials by the end of the decade.

If it sounds familiar, it might be because Star Trek thought of it first:

Image result for spock's brain

Homework: Capogrosso, Marco, Milekovic, Tomislav, et. al, A brain–spine interface alleviating gait deficits after spinal cord injury in primates, Nature

The Homemade Muon Detector October 15, 2016

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Dazzling in complexity, the little chart above details the fate of cosmic rays (high-energy protons hurtled from the sun) which impact our atmosphere, leaving a byzantine collection of particles and EM emissions.  Some of these suckers are relatively easy to detect; the muon possibly the easiest.  Scientists studying the output of our sun can use more information about cosmic ray bombardment and an array of muon detectors would be really useful for this as muons (and other particles) are generated within a cone-shaped shower, with all particles staying within about 1 degree of the primary particle’s path.

Enter Spencer Axani, doctoral student at Massachusetts Institute of Technology who has whomped one up for a mere hundred bucks, and published a paper with detailed construction plans (no Instructables project yet, however.  I checked):

image

Straightforward as heck, a plastic brick and a photomultiplier tube are locked up in a light-tight box.  Muons hit the brick, generate a photon on decay and the photomultiplier generates enough juice to tell there’s been an event. An Arduino is used (yes, an Arduino) as a peak detector and a Python script crunches the time-stamped data for delivery to a PC.

He took it around Fermilab to test it out in Real Life:

image

Neat-o, right?

 

Homework:  The Desktop Muon Detector: A simple, physics-motivated machine- and electronics-shop project for university students , S.N. Axani, J.M. Conrad, and C. Kirby, Physics Department, Massachusetts Institute of Technology, Cambridge, Mass.

Extra credit:  http://www2.fisica.unlp.edu.ar/~veiga/experiments.html

Universal Molecular Diagnostics by Affinity October 10, 2016

Posted by stuffilikenet in Awesome, Brilliant words, Science, Star Trek Technology, Toys.
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Rice University researchers have invented a technology that could potentially identify hundreds of bacterial pathogens simply, quickly and at low cost using a single set of random DNA probes. Richard Baraniuk, Amirali Aghazadeh and Rebekah Drezek whomped up a batch of five random probes and used them to identify 11 known strains of bacteria, providing a genomic-based test for identity of pathogens.  This is a big deal because usually each species required its own DNA probe.

Their new study includes several computer simulations, including one that shows how a random selection of five probes can identify 40 different strains of bacteria, and another that demonstrates how the system can accurately differentiate between 24 different species of Staphylococcus.

Rather than identifying a target strain based on a 100 percent match with a specific probe, Rice’s system tests how well the target DNA binds with several different random segments of complementary DNA. UMD uses a mathematical technique called compressive sensing, which was pioneered in the field of digital signal processing. With compressive sensing, the disease DNA need not bind with 100 percent of the probes. Instead, the new system measures how well the disease DNA binds with each of the random probes and creates a specific binding profile for the test organism. It then uses deductive reasoning to determine whether that profile matches the profile of any known pathogens.

With larger numbers of probes, it works even better:

No special hardware is required for this approach, other than the tried and true PCR with which we have become familiar over the last twenty years (thank you, Kary Mullis and LSD). The special sauce is the computer code which figures out the relative affinities.  This can be made available everywhere pretty cheaply, versus specialized DNA probes which require expensive facilities and a lot more regulatory testing.

Homework: Universal microbial diagnostics using random DNA probes, Amirali Aghazadeh1,*, Adam Y. Lin1,*, Mona A. Sheikh1,*, Allen L. Chen1, Lisa M. Atkins2, Coreen L. Johnson2, Joseph F. Petrosino2, Rebekah A. Drezek1 and Richard G. Baraniuk1, Science Advances  28 Sep 2016:Vol. 2, no. 9, e1600025 DOI:10.1126/sciadv.1600025

You Would be Smug, Too October 10, 2016

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https://cdn.arstechnica.net/wp-content/uploads/2016/10/bezos1-980x551.jpg

Jeff Bezos tweeted this picture of his boots and booze after completing a bucket of milestones in space exploration:

  1. Five flights of the same, reusable Blue Origin spacecraft within a year
  2. Separation of booster rocket and capsule with safe return for both
  3. Restart of booster rocket at only 3300 feet and safe return
  4. Safe return of capsule with one deliberately failed parachute.

The boots say “step by step, ferociously” in Latin. 

Smug and pretentious.  And well deserved.

Surface Chemistry Weekly Review September 19, 2016

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Things are happening in the thrilling world of surface chemistry (which I know you all care about deeply), so I will attempt to translate from Science to Normal and explain the usefulness of each advance (as I see it. I am never wrong).

First, and array of carbon nanotubes was created by drawing up a substrate from a solution of high-purity nanotubes, causing them to string out nicely.

Abstract Image

The resulting array of CNTs were etched with electrons scoring a resist coating, the remainder of which was washed off with acetone.  Not sure how they got the palladium contacts attached, but that may be just standard solution chemistry.  I can think of two ways to do it, if the CNTs can take it.

The upshot of all this is an array of CNT FETs (50 per micrometer!) with “quasi-ballistic conduction” (meaning really fast, almost effortless electron flow). As reported in Science “The saturated on-state current density is as high as 900 μA μm−1 and is similar to or exceeds that of Si FETs when compared at and equivalent gate oxide thickness and at the same off-state current density. The on-state current density exceeds that of GaAs FETs as well. This breakthrough in CNT array performance is a critical advance toward the exploitation of CNTs in logic, high-speed communications, and other semiconductor electronics technologies“, that last bit being a trifle understated.  This is equivalent to Silicon-based FETs, and more advances are coming.  This technology will most likely supplant silicon-base transistors in the not-too-distant future, giving you and me the ever-increasing computation speed and lower power demands that we associate with The Future of Computing.

Homework: Quasi-ballistic carbon nanotube array transistors with current density exceeding Si and GaAs, Science Advances  02 Sep 2016:Vol. 2, no. 9, Gerald J. Brady1, Austin J. Way, Nathaniel S. Safron1, Harold T. Evensen, Padma Gopalan and Michael S. Arnold

 

Next, Kiel University (Germany; it’s OK, I had to look it up, too) materials scientists found a way to microscopically etch metals so that they could be strongly joined by glue.  Their etching process results in a water- and grease-repellent metal surface which takes glue beautifully: “…the here described novel nanoscale-surface sculpturing based on semiconductor etching knowledge turns surfaces of everyday metals into their most stable configuration, but leaves the bulk properties unaffected.” Possible improvements to everyday life include surface prep for painting, aluminum removal from titanium implants and of course, using glue for metal parts assembly, which will save buckets of time and money, as welding is expensive and often impractical.

Not exactly surface chemistry, but I include it because I feel it’s a fundamental advance in materials science techniques.

Homework:  Making metal surfaces strong, resistant, and multifunctional by nanoscale-sculpturing, M. Baytekin-Gerngross et al, Nanoscale Horiz. (2016)

 

Materials researchers at North Carolina State University have developed a technique that allows them to integrate graphene, graphene oxide (GO) and reduced graphene oxide (rGO) on silicon at room temperature by using a nanosecond-pulsed laser.  They have foolishly tried to insist that this is to be used for medical sensors (and it may well be), but the reduced form of graphene oxide is a semiconducting material.  This could be an alternate route to large-scale manufacturing of graphene-based semiconductors, which means (once again) low-power, small devices for The Future of Computing.

Homework: Wafer scale integration of reduced graphene oxide by novel laser processing at room temperature in air, Anagh Bhaumik1 and Jagdish Narayan, J. Appl. Phys. 120, 105304 (2016)

That’s all for now.  Thanks for reading this far; you are very brave.

A Theory of High-temperature Superconductivity August 18, 2016

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Scientists at Brookhaven National Laboratory have a potential  explanation for high-temperature superconductivity of cuprates, the superconducting breakthrough of the 1980s. They theorize that a certain density of electron pairs is required and when the density is too small or too great, superconductivity disappears.

They painstakingly created many different cuprates with different amounts of doping to create cuprates (actually, 2500 different compounds of lanthanum, strontium copper and oxygen) with differing number of electron pairs using an amazing beam epitaxy system to create each compound layer by layer. Because cuprates have 50 atoms per unit cell, it’s very easy to get a mixture of compounds, so it’s hard to know what kind of result you are seeing. They fixed that problem with this:

https://i0.wp.com/cdn.phys.org/newman/gfx/news/hires/2016/10-scientistsun.jpg

This beam epitaxy system builds compounds layer by layer and has some awesome built-in surface chemistry tools, like an absorption spectrometer and an electron diffraction gizmo to monitor surface morphology, thickness, chemical composition, and crystal structure of the resulting thin films in real time.

This is exceptionally elegant work, and points to potential understanding of  a general theory which may help in finding room-temperature superconductors.

Homework: Dependence of the critical temperature in overdoped copper oxides on superfluid density , I. Božović, X. He, J. Wu & A. T. Bollinger

Science News Roundup August 12, 2016

Posted by stuffilikenet in Awesome, Brain, Geek Stuff, Science, Star Trek Technology, Uncategorizable.
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I haven’t had a lot of free time for stuff I like lately, but I didn’t want a few items from my science newsfeeds to go unnoticed by you, my adoring public. I expect most people don’t follow this kind of stuff closely, so pay attention:

First off, a team from the UK has found that a commonly available drug Fenamate can reduce the inflammation in a particular pathway to protect against a Alzheimer’s disease model in rodents. A mouse is not a man, but the results are intriguing enough (protected all rats in the study) that trials with humans are being strongly considered.  Because the drug is already approved for pain relief, the difficulty in getting into trials in the first place is enormously reduced. “In the USA, wholesale price of a week’s supply of generic mefenamic acid has been quoted as $426.90 in 2014. Brand-name Ponstel is $571.70. In contrast, in the UK, a weeks supply is £1.66, or £8.17 for branded Ponstan. In the Philippines, 10 tablets of 500 mg generic mefenamic acid cost PHP39.00 (or the equivalent of $0.88USD) as of October 25, 2014.”—Wikipedia.

Evil bastards? Well, sure. What do you expect from companies who can buy or sell legislators?

Next, paraplegic patients have had nerve and muscle function partially restored using a three-step training regimen in Brazil. Starting with VR to give them the sensation of walking through haptic feedback during brain-controlled maneuvering through a VR landscape, the patients then proceeded to move using a robotic walker on a treadmill with full support, also run through the brain-machine interface. Finally, they practiced walking with the robosuit used in that World Cup game a couple of years ago.  This took months, but the eight fully paralyzed patients who completed (one moved away) ALL showed some improvement.

This is a big deal.  None of these guys were ever supposed to get any sensation or control back.

This program is on-going, so we don’t know how much improvement will ultimately result from this innovative program, but I for one am pretty excited. Isn’t this why we work in computer science in the first place?

Nexus, Crux and Apex, by Ramez Naam July 1, 2016

Posted by stuffilikenet in Awesome, Books, Brilliant words, Geek Stuff, Star Trek Technology.
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These three novels are among the most interesting science fiction novels I have come across in some time..Lovingly detailed descriptions of the brain-nanoparticle operating system (Nexus) that allow people to hack their own brains, regulating mood, compelling actions and desires and enabling communication mind-to-mind seem plausible (after you swallow the sufficiently-advanced-technology bits) enough to support a tale of personal discovery by the author of the OS as he winds between the US government, Chinese spies, Thai drug lords and showdowns with the US government and a singularity’s intelligence. A good actioner, the story will compel your attention through all three books and make you wish for a different ending to the last one, for sure.

Highly recommended.  The links above go to Amazon, but are available at sfpl.org.

Housewife Replacement June 23, 2016

Posted by stuffilikenet in Applications, Awesome, Geek Stuff, Star Trek Technology, Toys.
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This is SpotMini from Boston Dynamics.  Usually BD makes enormous, noisy hulking robot mules to haul stuff around for the military…but the military said they were too loud and nixed the program.  So, here’s Spot, tidying up after breakfast.  All Spot needs now is the correct voice-activated response to “Get me a beer, will ya?” I see an enormous market for that.

Exciting update:

Told you so.

Silicon Valley Robotics Meetup June 17, 2016

Posted by stuffilikenet in Geek Stuff, Science, Star Trek Technology, Toys.
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I went a Meetup named Beer and Bots as part of Silicon Valley Robotics  in San Francisco (held at Comet Labs on Mission Street; thank you for your generosity) for a meeting featuring, well, beer and bots. 
It was almost all schmoozing, though there were three demos: An EE, who demonstrated a $150 black box robot platform (I have his card and will report more on this later);  Tap Interface guys tapwithus.com showing a Bluetooth gizmo for one-handed typing without a keyboard; and a robot gripper guy with a robust gripper that is fairly cheap, can hoist beer bottles despite guys trying to remove them by hand, but gentle enough to not wreck a tortilla chip (my test for gentleness).  Also met a recruiter from a contract robotics engineering firm, from whom I might get a little work here and there. Among other things I learned that Andra (boss of this little show) doesn’t have time to arrange any more robotics job fairs and is looking for someone to help with that kind of thing.  Could be me, maybe; I have some bandwidth coming available soon.

What It’s All For June 10, 2016

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Exciting update:

baby-octopus

OctoTranslator May 11, 2015

Posted by stuffilikenet in Applications, Awesome, Brilliant words, Geek Stuff, Star Trek Technology.
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is my latest app in the Google Play store (in fact my second). It is intended to help language learners create custom flash cards for use with Anki, which is possibly the best free flashcard program for Android phones (also available on iPhones, but who has those?).

Octotranslator - screenshot

OctoTranslator can take input from your microphone in any language your phone recognizes and can translate it to any language your phone can pronounce (this is called OctoTranslator because I used to have seven languages choices other than English…but I got upgrades, and so did OctoTranslator), by sending it to Microsoft Bing for translation (the same algorithm used in Skype).  It can return a text-only translation or it can read it to you using your Android phone’s TTS, which is pretty robust these days.  The real fun is saving to a data card to be mailed to you all zipped up in a single file, suitable for importing into Anki.

This is free. I would like reviews and testing, so feel free to take it and play with it, especially you Anki users, and lovers of foreign tongues (“My name is Inigo Montoya.  You killed my father. Prepare to die.”).

I must say I had fun testing this (I seem to have a macabre sense of humor when it comes to test phrases.  People overhearing me say things like “Spanish eyes is not really a casserole” and “Is your Mexican food made with real Mexicans?” make for real head-turning fun in line at the bank.  Takes the shine off it when they realize I’m joking, more’s the pity).

Get it here. (Offer not good after curfew in sectors R or M).

 

EXCITING, HORRIBLE UPDATE:

Octotranslator has died; “ArgumentException: Invalid authentication token. Microsoft DataMarket is retired. Please subscribe to Microsoft Translator, in the Cognitive Services section at https://portal.azure.com. Please visit https://cognitive.uservoice.com/knowledgebase/articles/1128340-announcements-action-required-before-april-30-20 to find detailed instructions. :” is the result.

I knew I should have paid Google instead.

 

EXCITING, WONDERFUL UPDATE:

Octotranslator has been reborn.  I went with Google Translation’s APIs, so you may continue.  I fixed a few glitches along the way, but users will not have noticed any of them anyway.