Gene Therapy Delivery System

GeT, pictured here above, is a model peptide sequence used to wrap around pEGFP, a gene that encodes fluorescent green stuff used in the proof-of-concept work described in the paper¹ published in Chemical Communications.  GeT “penetrates eukaryotic cells and promotes active DNA transport into mammalian cells (EGFP positive) by undergoing differential membrane-induced folding, which renders it both endosomolytic and antibacterial”–fancy talk meaning that we can start delivering gene therapies that have languished due to transport-into-living-cells issues.  I hope this gets the attention it needs from gene therapy/gene transfer researchers.

¹ GeT peptides: a single-domain approach to gene delivery, Baptiste Lamarre, Jascindra Ravi and Maxim G. Ryadnov, Chem. Commun., 2011, 47, 9045-9047