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Gene Therapy Delivery System August 17, 2011

Posted by stuffilikenet in Awesome, Science.


GeT, pictured here above, is a model peptide sequence used to wrap around pEGFP, a gene that encodes fluorescent green stuff used in the proof-of-concept work described in the paper1 published in Chemical Communications.  GeT “penetrates eukaryotic cells and promotes active DNA transport into mammalian cells (EGFP positive) by undergoing differential membrane-induced folding, which renders it both endosomolytic and antibacterial”–fancy talk meaning that we can start delivering gene therapies that have languished due to transport-into-living-cells issues.  I hope this gets the attention it needs from gene therapy/gene transfer researchers.

1 GeT peptides: a single-domain approach to gene delivery, Baptiste Lamarre, Jascindra Ravi and Maxim G. Ryadnov, Chem. Commun., 2011, 47, 9045-9047


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